Ovarian cancer is the leading cause of death among malignant tumors of the pelvic reproductive organs.
Furthermore, the cancer’s anatomical spread and intra-abdominal metastasis explain its severity and the fact that it is often diagnosed at a late stage, which accounts for its poor prognosis.
The risk factors are still not well understood. The use of oral contraceptives appears to reduce the risk of ovarian cancer.
Any suspicious ovarian lesion must undergo a comprehensive evaluation to determine its extent prior to surgery, which will also allow for tumor staging.
While an ultrasound can help establish a diagnosis, it cannot, on its own, determine the extent of this tumor—which is intraperitoneal (within the abdominal cavity)—or assess lymph node involvement.
An MRI provides an assessment of the extent of the condition, which will be reevaluated during the procedure—usually performed laparoscopically.
Only tumors that are localized, of low histological grade, and found in young women may be treated with a limited surgical procedure, such as the removal of the adnexa (fallopian tube and ovary) on one side, in order to preserve the patient’s fertility.
In most cases, the surgical procedure will be comprehensive, involving a hysterectomy, removal of the adnexa, an omentectomy (removal of the omentum), and a complete lymph node dissection (pelvic and lumbosacral).
The combination of surgery and chemotherapy is essential, and the order—whether surgery comes first or chemotherapy—does not matter.
This decision is made on a case-by-case basis during a multidisciplinary team meeting between the surgeon and the oncologists.